Dermamelan is a clinical-grade peel formulated by Mesoestic designed to address pigmentation issues, particularly melasma, post-inflammatory hyperpigmentation, and sun-induced pigmentation. It aims to reduce the appearance of dark spots, uneven skin tone, and pigmented blemishes.


15 minutes




Average 3-4 months


Treating static (permanent) or dynamic (with muscle movement) line/wrinkles caused by muscle contraction.


Hyperpigmentation occurs when an excess of melanin leads to darkened spots or patches on your skin. This is a global concern, but it is especially prominent here in Australia, where we experience high levels of ultraviolet radiation.

While sun exposure is the most well-known cause of pigmentation, it is only one of many factors that can contribute. Hyperpigmentation can also be triggered by hormonal changes, inflammatory conditions and some photosensitising drugs, as well as genetic influences.

Dermamelan offers a solution for those seeking clearer, more even-toned skin. By targeting the underlying causes of hyperpigmentation and working at the cellular level, Dermamelan not only lightens dark patches but also helps prevent their recurrence. Request a consultation to learn more about the hyperpigmentation treatment options available at Kaya Cosmedica.

Before and after comparison of a facial treatment. The left side shows a face with significant hyperpigmentation and freckles, and the right side shows the same face with noticeably reduced discoloration after

What Is Dermamelan?

The treatment protocol consists of an initial in-clinic consult followed by treatments in-clinic and an at-home skincare routine to promote deeper, longer-lasting results.

With this unique approach, Dermamelan offers a double corrective and regulatory action that can:

  • Correct existing pigmentation
  • Regulate melanin overproduction to limit the recurrence of spots


Dermamelan is the world’s leading medical depigmentation treatment. It can only be performed by a properly trained provider in a doctor-led clinic, such as Kaya Cosmedica in South Melbourne.

A close-up of a woman receiving a hyperpigmentation treatment, smiling with her eyes closed while a gloved hand applies Dermamelan to her forehead under warm lighting.

How Is Dermamelan Different From Cosmelan?

Both Dermamelan and Cosmelan are effective depigmentation treatments, but there are key differences between them.

Cosmelan is a milder aesthetic treatment and is suitable for less severe pigmentation. Dermamelan is a next-generation medical-grade depigmentation method. It is significantly stronger than Cosmelan, and therefore must only be used under a doctor’s supervision and monitoring.

Dermamelan’s groundbreaking formula allows for a more comprehensive and effective action when treating deeper and more stubborn pigmentation. This patented innovation can produce results after 6 months of treatment, making Dermamelan a more efficient and convenient protocol than Cosmelan.

How Does Dermamelan Work?

Dermamelan acts on the stratum corneum, stimulating epidermal renewal and intensively combating the build-up of melanin. The dermamelan acts by preventing pigmentation from reaching the superficial layers of the skin and also reducing the amount of melanin formed, reducing the intensity of the pigmented spot.

The Dermamelan protocol works through a dual-action mechanism that combines correction with a long-term regulating effect.

The Dermamelan protocol works through a dual-action mechanism that combines correction with a long-term regulating effect.

Corrective Benefits

Dermamelan actively reduces the accumulation of pigment in the skin’s superficial layer and encourages cell renewal. The combination of these actions helps to fade existing pigmentation and produce a brighter, more even complexion.

Preventative Benefits

Dermamelan also helps prevent the formation of new pigmentation by regulating the synthesis of melanin and preventing it from reaching the skin’s upper layers. This is achieved through the ingredients found in the protocol’s three home-use products.

Split image titled "dermamelan" showing a close-up of a person's nose and cheek area before and after melasma treatment. The 'after' photo shows reduced redness and pigmentation
Frequently asked questions

Take The First Step Towards A Clearer Complexion

At Kaya Cosmedica, our highly trained and experienced professionals will work closely with you to create a personalised treatment plan and ensure that you are well-informed at every step. We are dedicated to providing attentive, professional care using advanced technologies in a welcoming and sophisticated atmosphere.

We invite you to make an appointment with Dr. PK and the team in our South Melbourne clinic to explore your options for hyperpigmentation treatment. Book a consultation with us today.